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Eps8 Mouse, Unlabeled, Clone: 15, BD
Mouse Monoclonal Antibody
343.00€ - 675.00€
Especificaciones
Antígeno | Eps8 |
---|---|
Clon | 15 |
Concentración | 250μg/mL |
Aplicaciones | Western Blot |
Clasificación | Monoclonal |
Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
---|---|---|---|---|---|---|---|---|---|
Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
15815289
|
BD Biosciences
610143 |
50 μg |
343.00€
1 set |
Fecha estimada de envío: 16-05-2024 Inicie sesión para ver el stock |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | ||||
15825289
|
BD Biosciences
610144 |
150 μg |
675.00€
1 set |
Fecha estimada de envío: 16-05-2024 Inicie sesión para ver el stock |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | ||||
Descripción
The p97 [Eps8] protein, a substrate for EGF-R tyrosine kinase, contains an SH3 domain, but lacks a functional SH2 domain. Antibodies to Eps8 recognize the 97 kDa protein and a less abundant 68 kDa protein. Both forms are tyrosine-phosphorylated following treatment of cells with EGF. It is likely that p68 [Eps8] is synthesized from an alternatively spliced mRNA since two major Eps8-specific mRNAs are detected by Northern analysis. Co-immunoprecipitation studies have demonstrated a physical association between the Eps8 protein and the EGF-R both in vivo and in vitro. For many EGF-R substrates, this interaction is mediated through an SH2 domain of the substrate. Since Eps8 lacks a well defined SH2 domain and a fusion protein containing the SH2-like region of Eps8 could not bind EGF-R, the mechanism of Eps8-EGF-R association remains unclear. Overexpression of Eps8 in fibroblasts and hematopoietic cells results in an increased mitogenic response to EGF, suggesting that Eps8 has a role in the modulation of EGF-R function.
Especificaciones
Eps8 | |
250μg/mL | |
Monoclonal | |
Mouse | |
Cell Biology | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
IgG1 | |
Affinity Purified |
15 | |
Western Blot | |
Unconjugated | |
RUO | |
Canine, Human, Mouse, Rat | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
Primary | |
Store undiluted at -20°C. |
For Research Use Only.