missing translation for 'onlineSavingsMsg'
Learn More

eIF-5a Mouse, Unlabeled, Clone: 26, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 611976

Detalles adicionales : Peso : 0.01000kg

 Ver más versiones de este producto

Código de producto. 15826069

  • 252.00€ / 1 set


Fecha estimada de envío
06-09-2019
Añadir a la cesta

Descripción

Descripción

Initiation of eukaryotic translation involves a series of reactions mediated by multiple eukaryotic initiation factors (eIFs). However, one member of this family, eIF-5a, may have multiple protein functions. eIF-5a was originally identified as an initiation factor due to its binding of ribosomes, and its stimulation of methionyl-puromycin. Regulation of initiation may not be the major function of eIF-5a, since it functions as a targeting protein for the HIV protein, Rev, and the T-cell leukemia virus type 1 protein, Rex. In Xenopus oocytes, eIF-5a interacts with the nucleoporins Nup214, Nup153, Nup98, and Nup62, and is required for Rev-NES interaction with exportin1. These interactions may be involved with eIF-5a nuclear export of Rev protein, and eIF-5a requirement for Rev-mediated viral RNA export. eIF-5a is ubiquitously expressed, and is the only known eukaryotic protein that contains the post-translationally formed hypusine residue. Modification of eIF-5a with hypusine is coupled to cell proliferation, and disruption of this residue in yeast eIF-5a is lethal. Thus, eIF-5a may be an important nuclear transport protein with conserved function in many species.

Host Species: Mouse
Clone: 26
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human eIF-5a aa. 58-154

Bioimaging, Immunofluorescence, Western Blotting

Especificaciones

Especificaciones

eIF-5a
26
Unconjugated
Affinity Purified
Human eIF-5a aa. 58-154
50μg
Cell Biology
Primary
Canine, Chicken, Human, Murine, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Videos
Documentos

For Research Use Only.