missing translation for 'onlineSavingsMsg'
Learn More

Csk Mouse, Unlabeled, Clone: 52, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 610079

Detalles adicionales : Peso : 0.01000kg

 Ver más versiones de este producto

Código de producto. 15825249

  • 251.00€ / 1 set


Fecha estimada de envío
04-12-2019
Añadir a la cesta

Descripción

Descripción

The csk gene encodes a protein kinase that phosphorylates several Src family kinases including p60(c-src), p59(fyn), p53/56(lyn), p56(lck), and p62(yes). This phosphorylation occurs specifically at the carboxy-terminal tyrosine, Y527. Csk (c-src kinase) was identified based on its ability to phosphorylate exogenous Src in mammalian src-deficient cells. Establishment of a mouse csk- cell line revealed that phosphorylation of Y527 in Src was reduced 20-50%. This correlated with an increase of Src kinase activity, thus indicating Csk is a negative regulator of src. Csk-deficient cells also show an elevation in the kinase activity of p59(fyn) and p53/56(lyn). These data suggest that Csk may be a universal negative regulator of Src family kinases in vivo.

Host Species: Mouse
Clone: 52
Isotype: IgG1
Species Reactivity: Mouse
Immunogen: Rat Csk aa. 1-156
Formula Weight [Chemical]: 50kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Especificaciones

Especificaciones

Csk
52
Unconjugated
Affinity Purified
Rat Csk aa. 1-156
50μg
Cell Biology
Primary
Canine, Chicken, Human, Murine, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Videos
Documentos

For Research Use Only.