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CD62E Mouse anti-Human, Unlabeled, Clone: 68-5H11, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 555648
Detalles adicionales : Peso : 0.01000kg
Descripción
The 68-5H11 monoclonal antibody specifically binds to CD62E. This adhesion molecule is a 97-115 kDa type I transmembrane glycoprotein that is encoded by the SELE gene. CD62E is also known as E-selectin, Endothelial-leukocyte adhesion molecule-1 (ELAM-1), and Leukocyte endothelial cell adhesion molecule 2 (LECAM-2). CD62E is minimally expressed by unstimulated endothelium. Activated endothelial cells upregulate surface CD62E expression in response to various activators including inflammatory cytokines such as Interleukin-1 and Tumor Necrosis Factor. CD62E plays a role in leucocyte extravasation by promoting leucocyte rolling on activated endothelial cells during inflammation. CD62E may also play a role in the metastasis of certain tumor cells. The adhesion between endothelial CD62E molecules and a carbohydrate ligand on neutrophils is inhibited by the mAb 68-5H11.
Especificaciones
| CD62E | |
| Monoclonal | |
| 0.5mg/mL | |
| SELE; E-selectin; Selectin E; ELAM; ELAM1; ESEL; LECAM2 | |
| Mouse | |
| 0.1 mg | |
| Immunology | |
| Human | |
| IgG1 κ |
| Flow Cytometry | |
| 68-5H11 | |
| Unconjugated | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C |
For Research Use Only.