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CD40 Rat anti-Mouse, FITC, Clone: 3/23, BD

Rat Monoclonal Antibody

Marca:  BD Biosciences 553790

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15827398

  • 379.00€ / cada uno


Fecha estimada de envío
27-11-2019
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Descripción

Descripción

The 3/23 clone monoclonal antibody specifically binds to CD40, a 40-50 kDa glycoprotein expressed on B lymphocytes and other antigen-presenting cells. CD40 has been reported to be transiently expressed on activated CD4+ and CD8+ T cells and in some mouse strains, the 3/23 mAb has been reported to react with 5-10% of T lymphocytes in adult mouse, but not neonatal, spleen. CD40 plays a key role in B-cell growth and differentiation where interactions of CD40 with its ligand, CD154, are involved in the initiation, effector, and memory stages of cell-mediated immune responses. In addition, CD40 has been reported to be involved with the triggering of NK cells and NK-T cells. Ligation of CD40 with the 3/23 antibody has been reported to induce splenic B cells to express the costimulatory molecule CD86 (B7-2). In addition, although the 3/23 antibody by itself is a weak B-cell mitogen, it has been reported to synergize markedly with mitogenic anti-IgM, anti-IgD mAb or IL-4 to promote B-cell proliferation.

Especificaciones

Especificaciones

CD40
3/23
FITC
Affinity Purified
Mouse CD40 Recombinant Protein
0.5mg
Immunology
Primary
Murine
Flow Cytometry
0.5mg/mL
Aqueous buffered solution containing ≤0.09% sodium azide.
Rat
IgG2a, κ
RUO
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
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For Research Use Only.