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CD31 Rat anti-Mouse, FITC, Clone: MEC 13.3, BD

Rat Monoclonal Antibody

Marca:  BD Biosciences 553372

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15827188

  • 329.60€ / cada uno


Fecha estimada de envío
30-08-2019
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Descripción

Descripción

The MEC13.3 antibody reacts with CD31, also known as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1). CD31 is a 130 kDa integral membrane protein, a member of the immunoglobulin superfamily, that mediates cell-to-cell adhesion. CD31 is expressed constitutively on the surface of adult and embryonic endothelial cells and is also expressed on many peripheral leukocytes and platelets. It has also been detected on bone marrow-derived hematopoietic stem cells and embryonic stem cells. CD31 is involved in the transendothelial emigration of neutrophils, and neutrophil PECAM-1 appears to be down-regulated after extravasation into inflamed tissues. Multiple alternatively spliced isoforms are detected during early post-implantation embryonic development; this alternative splicing is involved in the regulation of ligand specificity. CD38 and vitronectin receptor (αvβ3 integrin, CD51/CD61) are proposed to be ligands for CD31. CD31-mediated endothelial cell-cell interactions are involved in angiogenesis. The MEC13.3 mAb inhibits a variety of in vitro and in vivo functions mediated by CD31.

Especificaciones

Especificaciones

CD31
MEC 13.3
FITC
Aqueous buffered solution containing ≤0.09% sodium azide.
Rat
IgG2a, κ
RUO
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
0.5mg/mL
PECAM-1
Affinity Purified
129/Sv mouse-derived endothelioma cell line tEnd.1
0.5mg
Immunology
Primary
Murine
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