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CD220 Mouse, Unlabeled, Clone: 46, BD
Mouse Monoclonal Antibody
343.00€ - 504.00€
Especificaciones
Antígeno | CD220 |
---|---|
Clon | 46 |
Concentración | 250μg/mL |
Aplicaciones | Western Blot |
Clasificación | Monoclonal |
Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
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Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
15815269
|
BD Biosciences
610109 |
50 μg |
343.00€
1 set |
Fecha estimada de envío: 15-05-2024 Inicie sesión para ver el stock |
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15825269
|
BD Biosciences
610110 |
150 μg |
Este artículo actualmente no está disponible o ha sido discontinuado. Ver la página del producto para posibles alternativas |
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Descripción
Insulin Receptor (IR) is a transmembrane receptor tyrosine kinase which, upon insulin binding, initiates a cascade of events, including autophosphorylation, phosphorylation of cellular protein substrates, glucose transport, and glycogen synthesis. IR is synthesized as a large glycosylated precursor that is cleaved upon maturation into a 130kDa α-subunit with kinase activity and a 95kDa β-subunit. The active Insulin Receptor is a heterotetramer of homologus α and β subunits joined by disulfide bonds. Among the major cytosolic substrates of the Insulin Receptor are IRS-1 and -2, β-Adrenergic receptor, and pp15 (adipocyte lipid-binding protein, ALBP). Autophosphorylation of the IR recruits IRS-1 and -2 to the phosphotyrosines. Subsequently, the phosphorylated IRS-1 and -2 act as docking sites for other signaling proteins like PI3-Kinase, Shc, PTP1D, Nck, etc. In addition, the phosphatase LAR is tightly associated with the IR and LAR becomes activated after insulin stimulation dephosphorylating the IR and its substrates. Therefore, LAR provides a turn-off mechanism in insulin signaling.
Host Species: Mouse
Clone: 46
Isotype: IgG1
Species Reactivity: Mouse
Immunogen: Human Insulin pro-receptor β subunit 1006-1144
Formula Weight [Chemical]: 95kDa
Immunofluorescence, Immunoprecipitation, Western Blotting
Especificaciones
CD220 | |
250μg/mL | |
Monoclonal | |
Mouse | |
Immunology | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
IgG1 | |
Affinity Purified | |
Insulin Receptor β |
46 | |
Western Blot | |
Unconjugated | |
RUO | |
Mouse, Rat | |
Human Insulin pro-receptor β subunit 1006-1144 | |
Primary | |
Store undiluted at -20°C. |
For Research Use Only.