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CD220 Mouse, Unlabeled, Clone: 46, BD

Mouse Monoclonal Antibody

251.00€ - 434.00€

Especificaciones

Antígeno CD220
Isotipo IgG1
Inmunógeno Human Insulin pro-receptor β subunit 1006-1144
Formulación Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugado Unconjugated
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Productos 2
Código de producto Marca Cantidad. Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad. Precio Cantidad y disponibilidad  
15815269 Ver documentos BD Biosciences
610109
50μg 251.00€
1 set Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío
12-12-2019
Añadir a la cesta
 
15825269 Ver documentos BD Biosciences
610110
150μg 434.00€
1 set Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío
12-12-2019
Añadir a la cesta
 
Descripción

Descripción

Insulin Receptor (IR) is a transmembrane receptor tyrosine kinase which, upon insulin binding, initiates a cascade of events, including autophosphorylation, phosphorylation of cellular protein substrates, glucose transport, and glycogen synthesis. IR is synthesized as a large glycosylated precursor that is cleaved upon maturation into a 130kDa α-subunit with kinase activity and a 95kDa β-subunit. The active Insulin Receptor is a heterotetramer of homologus α and β subunits joined by disulfide bonds. Among the major cytosolic substrates of the Insulin Receptor are IRS-1 and -2, β-Adrenergic receptor, and pp15 (adipocyte lipid-binding protein, ALBP). Autophosphorylation of the IR recruits IRS-1 and -2 to the phosphotyrosines. Subsequently, the phosphorylated IRS-1 and -2 act as docking sites for other signaling proteins like PI3-Kinase, Shc, PTP1D, Nck, etc. In addition, the phosphatase LAR is tightly associated with the IR and LAR becomes activated after insulin stimulation dephosphorylating the IR and its substrates. Therefore, LAR provides a turn-off mechanism in insulin signaling.

Host Species: Mouse
Clone: 46
Isotype: IgG1
Species Reactivity: Mouse
Immunogen: Human Insulin pro-receptor β subunit 1006-1144
Formula Weight [Chemical]: 95kDa

Immunofluorescence, Immunoprecipitation, Western Blotting

Especificaciones

Especificaciones

CD220
Human Insulin pro-receptor β subunit 1006-1144
Unconjugated
Immunology
Murine
Affinity Purified
Monoclonal
Insulin Receptor β
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
46
250μg/mL
Store undiluted at -20°C.

For Research Use Only.