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CD220 Mouse, Unlabeled, Clone: 46, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 610110
Detalles adicionales : Peso : 0.01000kg
Descripción
Insulin Receptor (IR) is a transmembrane receptor tyrosine kinase which, upon insulin binding, initiates a cascade of events, including autophosphorylation, phosphorylation of cellular protein substrates, glucose transport, and glycogen synthesis. IR is synthesized as a large glycosylated precursor that is cleaved upon maturation into a 130kDa α-subunit with kinase activity and a 95kDa β-subunit. The active Insulin Receptor is a heterotetramer of homologus α and β subunits joined by disulfide bonds. Among the major cytosolic substrates of the Insulin Receptor are IRS-1 and -2, β-Adrenergic receptor, and pp15 (adipocyte lipid-binding protein, ALBP). Autophosphorylation of the IR recruits IRS-1 and -2 to the phosphotyrosines. Subsequently, the phosphorylated IRS-1 and -2 act as docking sites for other signaling proteins like PI3-Kinase, Shc, PTP1D, Nck, etc. In addition, the phosphatase LAR is tightly associated with the IR and LAR becomes activated after insulin stimulation dephosphorylating the IR and its substrates. Therefore, LAR provides a turn-off mechanism in insulin signaling.
Host Species: Mouse
Clone: 46
Isotype: IgG1
Species Reactivity: Mouse
Immunogen: Human Insulin pro-receptor β subunit 1006-1144
Formula Weight [Chemical]: 95kDa
Immunofluorescence, Immunoprecipitation, Western Blotting
Especificaciones
CD220 | |
Monoclonal | |
250μg/mL | |
Insulin Receptor β | |
Mouse | |
Affinity Purified | |
RUO | |
Primary | |
Store undiluted at -20°C. |
Western Blot | |
46 | |
Unconjugated | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
Human Insulin pro-receptor β subunit 1006-1144 | |
150 μg | |
Immunology | |
Mouse, Rat | |
IgG1 |
For Research Use Only.