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CD220 Mouse, Unlabeled, Clone: 46, BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 610110

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15825269

  • 416.80€ / 1 set


Fecha estimada de envío
09-10-2019
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Descripción

Descripción

Insulin Receptor (IR) is a transmembrane receptor tyrosine kinase which, upon insulin binding, initiates a cascade of events, including autophosphorylation, phosphorylation of cellular protein substrates, glucose transport, and glycogen synthesis. IR is synthesized as a large glycosylated precursor that is cleaved upon maturation into a 130kDa α-subunit with kinase activity and a 95kDa β-subunit. The active Insulin Receptor is a heterotetramer of homologus α and β subunits joined by disulfide bonds. Among the major cytosolic substrates of the Insulin Receptor are IRS-1 and -2, β-Adrenergic receptor, and pp15 (adipocyte lipid-binding protein, ALBP). Autophosphorylation of the IR recruits IRS-1 and -2 to the phosphotyrosines. Subsequently, the phosphorylated IRS-1 and -2 act as docking sites for other signaling proteins like PI3-Kinase, Shc, PTP1D, Nck, etc. In addition, the phosphatase LAR is tightly associated with the IR and LAR becomes activated after insulin stimulation dephosphorylating the IR and its substrates. Therefore, LAR provides a turn-off mechanism in insulin signaling.

Host Species: Mouse
Clone: 46
Isotype: IgG1
Species Reactivity: Mouse
Immunogen: Human Insulin pro-receptor β subunit 1006-1144
Formula Weight [Chemical]: 95kDa

Immunofluorescence, Immunoprecipitation, Western Blotting

Especificaciones

Especificaciones

CD220
46
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
Insulin Receptor β
Affinity Purified
Human Insulin pro-receptor β subunit 1006-1144
150μg
Immunology
Primary
Murine, Rat
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For Research Use Only.