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CD11b Rat anti-Mouse, PE, Clone: M1/70, BD
Rat Monoclonal Antibody
Marca: BD Biosciences 553311
Detalles adicionales : Peso : 0.01000kg
Descripción
The M1/70 monoclonal antibody specifically binds to CD11b, also known as Integrin alpha M (Itgam or αM). CD11b is a 170-kDa type 1 transmembrane glycoprotein and belongs to the Integrin alpha chain family. CD11b serves as the alpha chain of the heterodimeric Mac-1 integrin (CD11b/CD18, αMβ2), also known as complement receptor 3 (CR3). Mac-1 mediates adhesion to ICAM-1 (CD54), ICAM-2 (CD102), fibrinogen and binding to C3bi. Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 B lymphocytes. Mac-1 expression is rapidly up-regulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface. The M1/70 antibody reportedly blocks cell adherence and C3bi binding but does not block cell-mediated lysis. Cross-reaction of the M1/70 antibody with CD11b expressed on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported.
Especificaciones
| CD11b | |
| Monoclonal | |
| 0.2mg/mL | |
| Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| M1/70 | |
| PE | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| C57BL/10 splenic T cells and concanavalin A-activated C57BL/10 splenocytes | |
| 0.2 mg | |
| Immunology | |
| Human, Mouse | |
| IgG2b κ |
For Research Use Only.