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CD11b Rat anti-Mouse, PE-Cy7, Clone: M1/70, BD

Rat Monoclonal Antibody

Marca:  BD Biosciences 552850

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15826878

  • 260.30€ / cada uno


Fecha estimada de envío
04-09-2019
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Descripción

Descripción

The M1/70 antibody reacts with the 170kDa α[M] chain of Mac-1 (CD11b/CD18, α[M]β[2] integrin), also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1 (CD54). Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 cells. Mac-1 expression is rapidly up-regulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface. M1/70 antibody reportedly blocks cell adherence and C3bi binding, but it does not block cell-mediated lysis. Cross-reaction of mAb M1/70 with CD11b on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Rat
Clone: M1/70
Isotype: IgG2b κ
Species Reactivity: Mouse
Immunogen: Mouse splenic Cells

Flow Cytometry

Especificaciones

Especificaciones

CD11b
M1/70
PE-Cyanine7
Aqueous buffered solution containing ≤0.09% sodium azide.
Rat
IgG2b, κ
RUO
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
0.2mg/mL
Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain
Affinity Purified
Mouse splenic Cells
0.1mg
Immunology
Primary
Human, Murine
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Documentos

For Research Use Only.