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CaM Kinase II Mouse, Unlabeled, Clone: 45, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 611293
Detalles adicionales : Peso : 0.01000kg
Descripción
Ca2+;/calmodulin-dependent protein kinase II (CaM kinase II) is a multifunctional Ser/Thr kinase that regulates a number of cellular functions in response to increased intracellular Ca2+;. CaM kinase II is widely distributed, but is predominantly expressed in brain. It is involved in the regulation of neuronal functions such as neurotransmitter synthesis, neurotransmitter release, long-term potentiation, and formation of spatial learning. Neuronal CaM kinase II contains heteromers of two major subunits, α and β, at a ratio of 2:1 and homomers of α subunits. Each subunit has N-terminal ATP-binding and catalytic/regulatory domains and a C-terminal association domain. The regulatory domain consists of the autoinhibitory and calmodulin-binding sites. Assembly of the association domains of multiple subunits positions the regulatory domains for intersubunit autophosphorylation. After binding Ca2+;/calmodulin, CaM kinase II undergoes rapid autophosphorylation of the α and β subunits, which results in a substantial increase in its affinity for Ca2+;/calmodulin.
Host Species: Mouse
Clone: 45
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Rat CaM Kinase IIα aa. 448-460
Formula Weight [Chemical]: 52kDa
Immunofluorescence, Immunohistochemistry, Western Blotting
Especificaciones
| CaM Kinase II | |
| Monoclonal | |
| 250μg/mL | |
| Ca2+/calmodulin-dependent protein kinase II | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at -20°C. |
| In vitro Assay, Western Blot | |
| 45 | |
| Unconjugated | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Rat CaM Kinase IIα aa. 448-460 | |
| 150 μg | |
| Cell Biology | |
| Canine, Human, Mouse, Rat | |
| IgG1 |
For Research Use Only.