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c-Raf Mouse, Unlabeled, Clone: 53, BD

Mouse Monoclonal Antibody

374.00€ - 595.00€

Especificaciones

Antígeno c-Raf
Clon 53
Concentración 250μg/mL
Aplicaciones Western Blot
Clasificación Monoclonal
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Productos 2
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
15895289
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BD Biosciences
610151
50 μg
374.00€
1 set
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Fecha estimada de envío: 22-04-2024
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15805299
Ver documentos Detalles de la promoción
BD Biosciences
610152
150 μg
595.00€
1 set
Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío: 16-04-2024
para ver el stock
Por favor, para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo.
Descripción

Descripción

Raf (c-Raf-1) is a cytoplasmic serine/threonine protein kinase and is a member of a family of proteins which are highly conserved from Drosophila to mammals. Raf has a critical role in the response to many growth factors including: EGF, PDGF, insulin, IL-2, IL-3, CSF-1, and GM-CSF. Raf can directly interact with Ras-GTP and subsequently become activated. Thus Raf plays a prominent role in the Ras signaling pathway by transferring a signal from Ras which has been activated by growth factor receptor-stimulated tyrosine kinase activity. This leads to the stimulation and activation of a number of other cytoplasmic serine/threonine kinases. Raf regulates the MAP kinase pathway by phosphorylating and activating MEK, which then phosphorylates and activates MAP kinase (ERK). ERK then phosphorylates and activates Rsk. Raf activity can also be regulated independently of Ras. Cyclic AMP (cAMP) activation of protein kinase A (PKA) can inhibit growth factor stimulation of Raf.

Especificaciones

Especificaciones

c-Raf
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
53
Western Blot
Unconjugated
RUO
Canine, Chicken, Human, Mouse, Rat
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Store undiluted at -20°C.
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