missing translation for 'onlineSavingsMsg'
Learn More

c-Myc with control Mouse anti-Human, Unlabeled, Clone: 9E10., BD

Mouse Monoclonal Antibody

Marca:  BD Biosciences 551101

Detalles adicionales : Peso : 0.02000kg

 Ver más versiones de este producto

Código de producto. 15826528

  • 241.00€ / cada uno


Fecha estimada de envío
12-11-2019
Añadir a la cesta

Descripción

Descripción

The myc gene family contains at least seven closely related genes, c-myc, N-myc, L-myc, P-myc, R-myc, S-myc, and B-myc. C-myc plays a role in proliferation, transformation, and differentiation. It is expressed during embryonic development, in a wide variety of adult tissues, and is amplified in many tumors, particularly lung, breast, cervical and colon carcinomas. Cellular localization has been described as nuclear and/or cytopasmic. C-myc has three sequence motifs in the carboxy terminus, a leucine zipper, a helix-loop-helix, and a basic region. It forms sequence-specific (CACGTG) DNA binding heterodimers with max, a helixloop-helix/leucine zipper protein. Both the leucine zipper domain and the helixloop-helix motif of c-myc contribute to heterodimer formation. DNA binding of myc-max dimers results in a conformational change of the DNA and transcriptional activation. C-myc migrates at 62 kDa in SDS-PAGE. Clone 9E10 recognizes human c-myc. A synthetic peptide corresponding to a C-terminal epitope of the human c-myc protein (AEEQKLISEEDL) was used as an immunogen.

Especificaciones

Especificaciones

c-Myc with control
9E10.
Affinity Purified
IgG1
RUO
Primary
Purified Mouse Anti-Human c-Myc (50μg); Jurkat Cell Lysate (50μg)
Western Blot
Unconjugated
Murine
50μg
Store undiluted at -20°C.
Monoclonal
Human
Videos
Documentos

For Research Use Only.