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Akt Mouse, Unlabeled, Clone: 55, BD
Mouse Monoclonal Antibody
381.00€ - 630.00€
Especificaciones
Antígeno | Akt |
---|---|
Clon | 55 |
Concentración | 250μg/mL |
Aplicaciones | Western Blot |
Clasificación | Monoclonal |
Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
---|---|---|---|---|---|---|---|---|---|
Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
15815679
|
BD Biosciences
610860 |
50 μg |
381.00€
1 set |
Fecha estimada de envío: 21-05-2024 Inicie sesión para ver el stock |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | ||||
15825679
|
BD Biosciences
610861 |
150 μg |
630.00€
1 set |
Fecha estimada de envío: 22-05-2024 Inicie sesión para ver el stock |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | ||||
Descripción
Akt [also known as PKB (Protein kinase B) or RAC-PK (Related to the A and C kinases] is a family of serine/threonine kinases that contains a pleckstrin homology (PH) domain. PH domains play important roles in signal transduction. There are three known isoforms of Akt in mammalian cells [Akt1 (α), Akt2 (β) and Akt3 (γ)]; they are thought to be regulated similarly. Akt is activated by insulin and growth factors by a mechanism involving phosphoinositide 3-OH kinase. Phosphoinositide 3-OH kinase products bind to the PH domain, resulting in translocation of Akt to the plasma membrane and activation of Akt to phospho-Akt by upstream kinases. Akt is phosphorylated within the activation loop at threonine 308 and the C-terminus at serine 473. Phospho-Akt promotes cell survival by inhibiting apoptosis. Specifically, phospho-Akt1 has been shown to phosphorylate Bad, a member of the Bcl-2 family that promotes cell death. This phosphorylation results in the inactivation of the proapoptotic function of Bad. The Akt molecule is thus considered to link extracellular survival signals (growth factors) with the apoptotic machinery (Bad). Akt is also a key mediator of the metabolic effects of insulin. Additionally, Akt has been referred to as an oncogene because it has increased activity in a number of tumors.
Immunofluorescence, Immunoprecipitation, Western Blotting
Especificaciones
Akt | |
250μg/mL | |
Monoclonal | |
Mouse | |
Cell Biology | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
IgG1 κ | |
Affinity Purified | |
PKBα, RAC-PK |
55 | |
Western Blot | |
Unconjugated | |
RUO | |
Canine, Human, Mouse, Rat | |
Human Akt1 Recombinant Protein | |
Primary | |
Store undiluted at -20°C. |
For Research Use Only.