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  6. Anfotericina B, Streptomyces nodosus, Thermo Scientific Chemicals

Anfotericina B, Streptomyces nodosus, Thermo Scientific Chemicals

Catalog Number 15454089
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Cantidad:
1 g
1397-89-3
C47H73NO17
924.09
MFCD00877763
APKFDSVGJQXUKY-ZNVUZQDLSA-N
134129663
ácido (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19Z,21Z,23Z,25Z,27Z,29Z,31Z,33R,35S,36R,37S)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihidroxi-6-metiloxan-2-il]oxi}-1,3,5,6,9,11,17,37-octahidroxi-15,16,18-trimetil-13-oxo-14,39-dioxabiciclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaeno-36-carboxílico
C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(O)=O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C/C=C\C=C/C=C\C=C/C=C\C=C/2)[C@@H](O)[C@@H](N)[C@@H]1O
1397-89-3
C47H73NO17
924.09
MFCD00877763
APKFDSVGJQXUKY-ZNVUZQDLSA-N
134129663
ácido (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19Z,21Z,23Z,25Z,27Z,29Z,31Z,33R,35S,36R,37S)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihidroxi-6-metiloxan-2-il]oxi}-1,3,5,6,9,11,17,37-octahidroxi-15,16,18-trimetil-13-oxo-14,39-dioxabiciclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaeno-36-carboxílico
C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(O)=O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C/C=C\C=C/C=C\C=C/C=C\C=C/2)[C@@H](O)[C@@H](N)[C@@H]1O

Descripción

Amphotericin B, CAS # 1397-89-3, is an antifungal that has been used against fungus caused by protozoan parasites of Leishmania genus.

Amphotericin B, antifungal activity has been used against leishmaniasis caused by protozoan parasites of the Leishmania genus. Amphotericin B trihydrate was observed to cause suppression of bone marrow progenitor cells and to induce Actinomycin D(CR001) sensitivity in drug resistant HELA cells in vitro.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Aplicaciones
La actividad antifúngica de la anfotericina B se ha utilizado contra la leishmaniasis causada por parásitos protozoarios del género Leishmania. Se ha observado que la anfotericina B trihidrato causa supresión de células progenitoras de médula ósea e induce sensibilidad a la actinomicina D (CR001) en células HELA resistentes a fármacos in vitro.

Solubilidad
Soluble en tampones acuosos a pH 2,0 u 11,0. Insoluble a pH 6,0-7,0. También soluble en DMSO o DMF.

Notas
Para uso exclusivo en investigación: no diseñado para uso diagnóstico o terapéutico en animales o humanos.
TRUSTED_SUSTAINABILITY
Nombre del producto químico o material Amphotericin B
Tipo Amphotericin B
Nombre de nota Streptomyces nodosus
Forma física Polvo
Beilstein 78342
Índice Merck 14,585
Información de solubilidad Soluble in aqueous buffers at pH 2;0 or 11;0; Insoluble at pH 6;0-7;0; Also soluble in DMSO or DMF
Formula Weight (peso de la fórmula) 924.1
Color Amarillo
Cantidad 1 g
Sensibilidad Light and moisture sensitive
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RUO – Research Use Only

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