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Amphiregulin Mouse anti-Human, PE, Clone: AREG559, eBioscience™

Mouse Monoclonal Antibody

Marca:  Invitrogen 12-5370-41

Detalles adicionales : Peso : 0.01000kg

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Código de producto. 15933174

  • 119.00€ / paquete de 25


Fecha de envío estimada
del proveedor 28-10-2019
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Descripción

Descripción

Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252-amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGFalpha, AR, HB-EGF, cripto-1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF-like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.
Especificaciones

Especificaciones

Amphiregulin
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P15514
Amphiregulin; amphiregulin B; AR; Colorectum cell-derived growth factor; CRDGF; Schwannoma-derived growth factor; SDGF
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
AREG559
PE
AREG
Liquid
AREG
IgG1, kappa
25 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
374
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