alpha-SNAP Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Descripción

This antibody recognizes a 33 kDa protein in SDS page.

SNAPs (solubleNSFattachment proteins), acting in concert with SNAREs (S N A P r e c eptors) and the N - ethylmaleimide- s e nsitive f u sion protein (NSF) are required for the fusion of transport vesicles to their target membranes in synaptic transmission, intra-Golgi transport, endosome-toendosome fusion and transcytotic vesicles-to-plasma membrane transport. Vesicle-to-target membrane docking (initial contact) occurs when the vesicle SNARE binds to its cognate target membrane SNARE. a-SNAP (or b-SNAP in brain) then binds to this docking complex and mediates the binding of NSF and thus the formation of a 20S fusion particle. It is thought that, once NSF is bound, ATP hydrolysis by NSF initiates the fusion process.