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AKAP3 Mouse anti-Human, Mouse, Clone: 3C11H9, Proteintech

Mouse Monoclonal Antibody

Marca:  Proteintech 66255-1-IG-150UL

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16817965

  • 319.00€ / 150 microlitros

Envío estimado: 21-10-2021

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Descripción

Descripción

The type II cAMP-dependent protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins, designated A-kinase anchoring proteins (AKAP). AKAP 3, also known as AKAP 110, FSP95, PRKA3 and SOB1, binds both PKA and PDE4A and functions as a scaffolding protein in spermatozoa to regulate local cAMP concentrations and modulate sperm functions. Expression of AKAP 3 in normal tissues is restricted to the testis, where bicarbonate stimulates tyrosine phosphorylation of AKAP 3, thereby increasing its recruitment of PKA. AKAP-3 also exhibits high expression in patients with epithelial ovarian cancer (EOC). It demonstrates tumor-restricted expression and appears to be associated with worse overall survival, which make AKAP 3 a potential target for antigen-specific immunotherapy in EOC.
Especificaciones

Especificaciones

AKAP3
3C11H9
Unconjugated
AKAP3
Liquid
AKAP3
AKAP3 Fusion Protein Ag4885
Protein A
RUO
Antibody
Monoclonal
Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
1.76 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O75969, O88987
A kinase anchor protein 3, AKAP 110, AKAP 3, AKAP110, AKAP3, Cancer/testis antigen 82, CT82, Fibrousheathin 1, Fibrousheathin I, FSP95, PRKA3, SOB1, Sperm oocyte binding protein
Mouse
IgG2a
150 μL
-20°C
Primary
10566, 11642
Videos
SDS
Documentos
Certificados