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Bovine calf serum is a cost-effective alternative to Fetal Bovine Serum (FBS). It is often used with robust cell lines when large quantities of serum are needed such as in the manufacturing of biological drugs and vaccines. Bovine calf serum is derived from calves that are generally less than 22 weeks old. It has very high levels of transferrin, which allows for iron fortification to levels of more than three times greater than FBS.