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GDF5 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marca: Invitrogen PA529775
Detalles adicionales : Peso : 0.01000kg
Descripción
Recommended positive controls: IMR32. Predicted reactivity: Human (99%), Mouse (96%), Pig (98%), Rabbit (98%), Chicken (83%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Hunter-Thompson type dwarfism and in Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino acid signal peptide and a 354 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease.Especificaciones
GDF5 | |
Polyclonal | |
Unconjugated | |
GDF5 | |
BDA1C; Bmp14; BMP-14; Bone morphogenetic protein 14; bp; brachypodism; brp; Cartilage-derived morphogenetic protein 1; cartilage-derived morphogenetic protein-1; CDMP1; Cdmp-1; GDF5; GDF-5; growth differentiation factor 5; growth/differentiation factor 5; H-GDF-5; LAP4; LAP-4; Lipopolysaccharide-associated protein 4; LPS-associated protein 4; OS5; radotermin; SYM1B; SYNS2 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
8200 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Functional Assay, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
0.65 mg/mL | |
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 | |
P43026 | |
GDF5 | |
Recombinant fragment corresponding to a region within amino acids 169 and 501 of Human GDF5 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |